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Of Two Make One: The Biosynthesis of Phenazines
Author(s) -
Mentel Matthias,
Ahuja Ekta G.,
Mavrodi Dmitri V.,
Breinbauer Rolf,
Thomashow Linda S.,
Blankenfeldt Wulf
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900323
Subject(s) - biosynthesis , operon , virulence , enzyme , biochemistry , chemistry , antibiotics , microbiology and biotechnology , biology , gene , escherichia coli
Five easy steps : Phenazines are redox‐active bacterial secondary metabolites that possess broad‐specificity antibiotic activity and can also play an important role as virulence factors in infectious disease. Their biosynthesis from two molecules of chorismic acid is catalyzed by enzymes encoded in the conserved phz operon.