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Multivalent Manno‐Glyconanoparticles Inhibit DC‐SIGN‐Mediated HIV‐1 Trans‐Infection of Human T Cells
Author(s) -
MartínezÁvila Olga,
Bedoya Luis M.,
Marradi Marco,
Clavel Caroline,
Alcamí José,
Penadés Soledad
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900294
Subject(s) - dc sign , nanoclusters , human immunodeficiency virus (hiv) , peripheral blood mononuclear cell , mannose , sign (mathematics) , chemistry , stereochemistry , nanotechnology , virology , biology , in vitro , immunology , materials science , antigen , biochemistry , dendritic cell , mathematics , mathematical analysis
Gold simplifies matters : Gold manno‐glyconanoparticles displaying different densities of linear and branched mannose oligosaccharides acted as inhibitors of DC‐SIGN‐mediated HIV trans ‐ infection of human activated peripheral blood mononuclear cells. Presentation of simple linear di‐, tri‐, and tetraoligosaccharides on the nanoclusters resulted in efficiencies similar to those observed for complex branched penta‐ and heptamannosides.