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Expanding RNA Silencing Approaches by U1 Adaptors
Author(s) -
Grünweller Arnold,
Hartmann Roland K.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900271
Subject(s) - polyadenylation , gene silencing , rna splicing , rna induced silencing complex , exon , snrnp , computational biology , messenger rna , biology , microbiology and biotechnology , rna , genetics , gene , rna interference
Silent partner : In a recent publication, Gunderson and co‐workers described an approach to recruit the abundant U1 snRNP, a splicing subparticle, to the last exon of a pre‐mRNA, in a sequence‐specific manner. This mediates interaction of the U1‐70K protein subunit with poly(A) polymerase, thus blocking polyadenylation and inducing pre‐mRNA degradation. This novel promising strategy expands the repertoire of gene‐silencing concepts.