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Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli
Author(s) -
Watanabe Kenji,
Hotta Kinya,
Praseuth Alex P.,
Searcey Mark,
Wang Clay C. C.,
Oguri Hiroki,
Oikawa Hideaki
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900260
Subject(s) - biosynthesis , depsipeptide , synthetic biology , escherichia coli , scope (computer science) , biochemistry , chemistry , computational biology , enzyme , biology , gene , computer science , programming language
Drugs from bugs . We have successfully expanded the scope of our E. coli ‐based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.