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Targeting Higher‐Order DNA: Beyond the G‐Quadruplex
Author(s) -
Howell Lesley A.,
Searcey Mark
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900243
Subject(s) - g quadruplex , dna , computational biology , chemistry , small molecule , biophysics , nanotechnology , biology , biochemistry , materials science
There must be more to DNA than this : The G‐quadruplex is a higher‐order DNA structure that is of interest as a potential therapeutic target. However it is not the only structure to bind small‐molecule ligands, and in this minireview we describe recent studies of molecules that target three‐way and four‐way junctions.