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Evaluation of β‐Alanine‐ and GABA‐Substituted Peptides as Inhibitors of Disease‐Linked Protein Aggregation
Author(s) -
Madine Jillian,
Wang Xiaoyan,
Brown David R.,
Middleton David A.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900219
Subject(s) - chemistry , peptide , alanine , amino acid , biochemistry , protein aggregation , alzheimer's disease , disease , pharmacology , medicine
Inhibition of amyoid formation—the β‐peptide way : Introducing β‐amino acids into short peptides is presented as a novel method of preventing aggregation of amyloid proteins. The data suggest a common precursor to design agents to treat Lewy body disease, Alzheimer's and type 2 diabetes.