Bipartite Tetracysteine Display Requires Site Flexibility for ReAsH Coordination | Zendy

Goodman Jessica L. | Zendy; Fried Daniel B. | Zendy; Schepartz Alanna | Zendy

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Bipartite Tetracysteine Display Requires Site Flexibility for ReAsH Coordination

Author(s) -

Goodman Jessica L.,

Fried Daniel B.,

Schepartz Alanna

Publication year - 2009

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200900207

Subject(s) - flexibility (engineering) , bipartite graph , intramolecular force , binding site , chemistry , nanotechnology , computer science , stereochemistry , materials science , biochemistry , theoretical computer science , mathematics , graph , statistics

Flexibility required : We designed intramolecular bipartite tetracysteine sites in loops of p53 and the β‐sheets of EmGFP. We found that ReAsH binding preferentially favors tetracysteine sites with flexible geometries such as loops; flexibility was assessed by comparing Cα B‐factor values. This information is important for directing successful bipartite tetracysteine site designs.

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