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Evidence for Pseudoknot Formation of Class I preQ 1 Riboswitch Aptamers
Author(s) -
Rieder Ulrike,
Lang Kathrin,
Kreutz Christoph,
Polacek Norbert,
Micura Ronald
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900155
Subject(s) - pseudoknot , riboswitch , aptamer , computational biology , knot (papermaking) , chemistry , biology , nanotechnology , rna , genetics , biochemistry , non coding rna , materials science , gene , composite material
All in a knot . The smallest riboswitch forms a pseudoknot in solution. This is demonstrated for preQ 1 class I aptamers by mutational analysis in combination with 1 H NMR‐based structure probing. How pseudoknot formation mediates the mRNA response through its expression platform is now open for investigation.