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The Natural Products Beauveriolide I and III: a New Class of β‐Amyloid‐Lowering Compounds
Author(s) -
Witter Daniel P.,
Chen Yanping,
Rogel Joseph K.,
Boldt Grant E.,
Wentworth Paul
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900139
Subject(s) - senile plaques , amyloid (mycology) , chemistry , secretion , bioavailability , amyloid precursor protein , alzheimer's disease , biochemistry , β amyloid , amyloid beta , disease , peptide , pharmacology , biology , medicine , inorganic chemistry
Attacking Alzheimer's by ACAT : The aggregation of β‐amyloid peptides, especially Aβ 42 , into senile plaques is a hallmark of Alzheimer's disease (AD). We show that the fungal natural products beauveriolides I and III can potently decrease Aβ secretion from cells expressing human amyloid precursor protein; this offers a potential new scaffold for the development of compounds with proven bioavailability for the treatment of AD.