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Synthesis and Investigation of Tryptophan–Amphotericin B Conjugates
Author(s) -
Zumbuehl Andreas,
Stano Pasquale,
Sohrmann Marc,
Dietiker Rolf,
Peter Mathias,
Carreira Erick M.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900096
Subject(s) - amphotericin b , tryptophan , conjugate , sterol , liposome , chemistry , stereochemistry , membrane , combinatorial chemistry , biochemistry , biology , microbiology and biotechnology , cholesterol , amino acid , antifungal , mathematical analysis , mathematics
Anchors aweigh! The synthesis of tryptophan–amphotericin B conjugates (see figure) is described. The membrane‐anchoring effect of tryptophane was thus combined with the pore‐formation effect of amphotericin B leading to high channel activity in sterol‐free liposomes.