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Synthesis and Application of Peptide Arrays: Quo Vadis SPOT Technology
Author(s) -
Volkmer Rudolf
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900078
Subject(s) - computer science , status quo , peptide synthesis , peptide , nanotechnology , combinatorial chemistry , chemistry , materials science , biochemistry , political science , law
Hitting the SPOT : In 1992, Ronald Frank published the first seminal paper on simultaneous parallel synthesis of multiple peptides on filter paper. He defined the approach as SPOT synthesis, an easy technique for positionally addressable, parallel chemical synthesis on a membrane support. Here, a basic overview of this technology is presented and a recently published applications are highlighted. At the end, the future of peptide arrays is discussed.