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A Pan‐Specific Inhibitor of the Polo‐Box Domains of Polo‐like Kinases Arrests Cancer Cells in Mitosis
Author(s) -
Reindl Wolfgang,
Yuan Juping,
Krämer Andrea,
Strebhardt Klaus,
Berg Thorsten
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900059
Subject(s) - polo like kinase , plk1 , kinase , mitosis , microbiology and biotechnology , function (biology) , small molecule , biology , biochemistry , chemistry , cell cycle , gene
Playing polo : Small‐molecule inhibitors of polo‐like kinase 1 are mostly ATP‐competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small‐molecule inhibitor of the protein–protein interactions required for Plk1 function.