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Design of Protein–Protein Interaction Inhibitors Based on Protein Epitope Mimetics
Author(s) -
Robinson John A.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900055
Subject(s) - epitope , scaffold , protein design , scaffold protein , chemistry , computational biology , protein–protein interaction , protein engineering , target protein , protein structure , biochemistry , biology , computer science , antibody , signal transduction , enzyme , database , gene , immunology
On the scaffold : Grafting protein epitopes onto conformationally designed scaffolds represents a very promising approach to protein ligand design, with potential applications in many areas of chemical biology and molecular medicine. The highlighted article describes the design and anticancer activity of novel p53/MDM2 inhibitors built upon a scorpion toxin scaffold. Other approaches to protein epitope mimetics are also briefly discussed.