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The Engineering of Bacteria Bearing Azido‐Pseudaminic Acid‐Modified Flagella
Author(s) -
Liu Feng,
Aubry Annie J.,
Schoenhofen Ian C.,
Logan Susan M.,
Tanner Martin E.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900018
Subject(s) - flagellum , bacteria , azide , mutant , chemistry , biochemistry , biology , organic chemistry , gene , genetics
Catch a tiger by the tail : We have demonstrated that by feeding nonmotile mutant C. jejuni bacteria with a neutral azide‐labelled pseudaminic acid precursor we can restore their ability to generate functional flagella. The presence of azido‐pseudaminic acid on the surface of the flagella provides a bio‐orthogonal chemical handle that can be used to modify the flagellar proteins.
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