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The Puzzle of RNAs that Target Gene Promoters
Author(s) -
Younger Scott T.,
Corey David R.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900015
Subject(s) - biology , promoter , rna , gene , gene expression , rna interference , dna , computational biology , messenger rna , genetics , long non coding rna , regulation of gene expression , microbiology and biotechnology
Setting the right target : Most researchers who use small RNAs in mammalian cells assume that mRNA will be the target. Recent studies suggest that small RNAs can also target chromosomal DNA.Few discoveries have had the impact of RNAi. Most researchers who use small RNAs to control gene expression in mammalian cells assume that mRNA will be the target. Recent studies, however, have suggested that small RNAs can also target chromosomal DNA.