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Blue‐Light‐Triggered Photorelease of Active Chemicals Captured by the Flavoprotein Dodecin
Author(s) -
Nöll Gilbert,
Trawöger Sibylle,
von SandenFlohe Madlene,
Dick Bernhard,
Grininger Martin
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900014
Subject(s) - flavoprotein , riboflavin , flavin group , chemistry , biophysics , biochemistry , combinatorial chemistry , enzyme , biology
Learning from nature : In nature, riboflavin binding proteins are responsible for the transport and release of riboflavin. Here, the development of a molecular photorelease system based on the riboflavin binding protein dodecin is presented. Any drug or active chemical linked to a flavin can be captured by dodecin and transported to a location of interest. Irradiation with blue light results in the release of the ligands.