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Cover Picture: Indoloquinolizidine Derivatives as Novel and Potent Apoptosis Inducers and Cell‐Cycle Blockers (ChemBioChem 3/2008)
Author(s) -
Wehner Frank,
NörenMüller Andrea,
Müller Oliver,
ReisCorrêa Ivan,
Giannis Athanassios,
Waldmann Herbert
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200890004
Subject(s) - apoptosis , cell cycle , inducer , programmed cell death , derivative (finance) , cover (algebra) , chemistry , front cover , stereochemistry , microbiology and biotechnology , biology , biochemistry , gene , financial economics , engineering , economics , mechanical engineering
The cover picture shows an indoloquinolizidine derivative that has been identified as a potent cell‐death‐inducing (apoptosis) agent, after the screening of 11 000 natural‐product‐derived and ‐inspired compounds in three human tumour cell lines. The background shows the stark white branches of a dead tree in front of the green of a living one, while the blue sea in the distance symbolises (unreachable) eternity. FACS analysis indicated that the derivative shown is one of seven compounds that are able to arrest cells in the G 2 M phase of the cell cycle. For more details see the article by F. Wehner et al. on p. 401 ff.