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Protein Iodination by Click Chemistry
Author(s) -
Dong Shouliang,
Moroder Luis,
Budisa Nediljko
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800816
Subject(s) - click chemistry , moiety , halogenation , chemistry , azide , iodine , covalent bond , protein chemistry , alkyne , combinatorial chemistry , organic chemistry , biochemistry , catalysis
Abstract Two steps to click iodine : We have developed a two‐step reaction for protein iodination using click chemistry. With this method, which is summarized in the scheme, covalent attachment of a stable iodine‐containing aromatic azide moiety to an alkyne‐containing protein was achieved.