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Structurally Refined β‐Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors
Author(s) -
Böttcher Thomas,
Sieber Stephan A.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800743
Subject(s) - virulence , microbiology and biotechnology , regulator , biology , toxin , superantigen , staphylococcus aureus , bacteria , virulence factor , pathogenic bacteria , immune system , gene , immunology , genetics
Disarmed forces : Inhibition of the central virulence regulator ClpP by structurally refined β‐lactones resulted in dramatically reduced production of devastating virulence factors, including pyrogenic toxin superantigens derived from pathogenic multiresistant Staphylococcus aureus strains. Targeting of this virulence regulator could present an attractive strategy for neutralizing the harmful effects of bacterial pathogens, and help the host immune response to eliminate the disarmed bacteria.