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Design of Cell‐Surface‐Retained Polymers for Artificial Ligand Display
Author(s) -
Kamitani Ryosuke,
Niikura Kenichi,
Okajima Takaharu,
Matsuo Yasutaka,
Ijiro Kuniharu
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800621
Subject(s) - cationic polymerization , polymer , internalization , ligand (biochemistry) , combinatorial chemistry , amine gas treating , computer science , cell , chemistry , surface modification , nanotechnology , biochemistry , materials science , organic chemistry , receptor
We propose a cell‐surface modification method based on the use of synthetic polymers that can be retained on the cell surface without rapid internalization. Secondary amine‐displaying cationic polymers act as an effective scaffold for the display of artificial ligands, thus affording a new technique for the control of cell adhesion events through the specific recognition of these ligands.