Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines | Zendy

Stump Bernhard | Zendy; Eberle Christian | Zendy; Schweizer W. Bernd | Zendy; Kaiser Marcel | Zendy; Brun Reto | Zendy; KrauthSiegel R. Luise | Zendy; Lentz Dieter | Zendy; Diederich François | Zendy

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Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines

Author(s) -

Stump Bernhard,

Eberle Christian,

Schweizer W. Bernd,

Kaiser Marcel,

Brun Reto,

KrauthSiegel R. Luise,

Lentz Dieter,

Diederich François

Publication year - 2009

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800565

Subject(s) - chemistry , enzyme , antiprotozoal , substituent , biochemistry , in vitro , stereochemistry , pharmacology , biology

Pentafluorosulfanyl power! The SF 5 group—a novel substituent with striking physicochemical properties—was used as building block for trypanothione reductase (TR) inhibitors and compared to its CF 3 and C(CH 3 ) 3 relatives. The high in vitro activities of these derivatives against Trypanosoma brucei rhodesiense as well as against Plasmodium falciparum supports the suitability of SF 5 as a component of drug‐like compounds.

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