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Effects of Asymmetric Arginine Dimethylation on RNA‐Binding Peptides
Author(s) -
Hyun Soonsil,
Jeong Sunjoo,
Yu Jaehoon
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800544
Subject(s) - methylation , arginine , epigenetics , rna , biochemistry , computational biology , peptide , chemistry , rna binding protein , biology , amino acid , dna , gene
On and off : Arginine methylation is a frequent epigenetic change in RNA‐binding proteins. Here, using a number of modified proteins, we demonstrated that a variety of binding affinity changes occur upon arginine methylation of Rev peptide. α Helicity, reductions of H bonds, and increase of hydrophobic interactions are three major factors that alter affinity. This methylation could be used as a reversible switch to differentiate protein–RNA interactions in a selective manner.