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Self‐Assembling Polyethylenimine Derivatives Mediate Efficient siRNA Delivery in Mammalian Cells
Author(s) -
Creusat Gaelle,
Zuber Guy
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800540
Subject(s) - polyethylenimine , cationic polymerization , chemistry , tyrosine , combinatorial chemistry , amino acid , transfection , microbiology and biotechnology , biophysics , biochemistry , biology , organic chemistry , gene
Simple and efficient : In this study, we examined the relationships between siRNA delivery efficacy and aggregating properties for different amino acid‐modified polyethylenimines (PEIs). Full modification of the primary amines of PEI with tyrosine enables the polymer to self‐assemble into cationic particles and to convey siRNA into mammalian cells very efficiently, even in the presence of serum.