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Molecular Basis for β‐Glucosidase Inhibition by Ring‐Modified Calystegine Analogues
Author(s) -
Aguilar Matilde,
Gloster Tracey M.,
GarcíaMoreno M. Isabel,
Ortiz Mellet Carmen,
Davies Gideon J.,
Llebaria Amadeu,
Casas Josefina,
EgidoGabás Meritxell,
García Fernandez José M.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800451
Subject(s) - thermotoga maritima , stereochemistry , chemistry , ring (chemistry) , derivative (finance) , alkaloid , biochemistry , organic chemistry , gene , escherichia coli , financial economics , economics
Neutral calystegine B 2 analogues , such as the 1‐deoxy‐6‐oxa‐ N ‐( N′ ‐octyl)thiocarbamoyl derivative, proved to be more potent β‐glucosidase inhibitors than the natural alkaloid. Structural studies of the complex with a clan GH‐A β‐glucosidase from Thermotoga maritima showed a binding mode markedly different from that of the parent compound.