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A Simple Cytosine to G‐Clamp Nucleobase Substitution Enables Chiral γ‐PNAs to Invade Mixed‐Sequence Double‐Helical B‐form DNA
Author(s) -
Chenna Venugopal,
Rapireddy Srinivas,
Sahu Bichismita,
Ausin Cristina,
Pedroso Enrique,
Ly Danith H.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800441
Subject(s) - nucleobase , dna , stereochemistry , cytosine , sequence (biology) , chemistry , base pair , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , substitution (logic) , a dna , crystallography , biochemistry , computer science , programming language
Watson–Crick recognition of double‐helical B‐form DNA by Chiral γ‐PNAs : C→G‐clamp (X) nucleobase substitution provides the necessary binding free energy for chiral γ‐PNAs to invade mixed‐sequence B‐DNA.