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Potentially Prebiotic Synthesis of Pyrimidine β‐ D ‐Ribonucleotides by Photoanomerization/Hydrolysis of α‐ D ‐Cytidine‐2′‐Phosphate
Author(s) -
Powner Matthew W.,
Sutherland John D.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800391
Subject(s) - cytidine , prebiotic , nucleotide , hydrolysis , pyrimidine , nucleobase , chemistry , phosphate , rna , biochemistry , combinatorial chemistry , enzyme , gene , dna
Prebiotic nucleotide synthesis: two for the price of one! Photoanomerization of α‐ D ‐cytidine is extremely low yielding, but irradiation of the 2′‐phosphate results in efficient anomerization and nucleobase hydrolysis such that both pyrimidine nucleotides needed for prebiotic RNA synthesis are produced in a single reaction.