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Embryonic Stem Cells: The Mouse Source—Vehicle for Mammalian Genetics and Beyond (Nobel Lecture)
Author(s) -
Evans Martin
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800352
Subject(s) - embryonic stem cell , biology , context (archaeology) , stem cell , embryo , genetics , microbiology and biotechnology , developmental biology , gene , paleontology
The story of mouse ES cells : Here, Martin Evans discusses the studies which led up to the discovery of mouse ES cells and their use for experimental mammalian egnetics, initially exemplified by using retroviral vectors. ES cells allow new, specifically targeted mutations to be tested in the context of the whole animal. ES cells are shown to be identical to a cell type in the normal mouse embryo. This work was honoured with the 2007 Nobel Prize for Physiology or Medicine