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Amyloid Fibrillar Meshwork Formation of Iron‐Induced Oligomeric Species of Aβ40 with Phthalocyanine Tetrasulfonate and Its Toxic Consequences
Author(s) -
Park JaeWoo,
Ahn Jung Sun,
Lee JungHo,
Bhak Ghibom,
Jung Seunho,
Paik Seung R.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800343
Subject(s) - prion protein , amyloid (mycology) , chemistry , solubilization , phthalocyanine , amyloid β , biophysics , biochemistry , nanotechnology , materials science , biology , medicine , organic chemistry , pathology , inorganic chemistry , disease
Brain detoxification : Phthalocyanine tetrasulfonate (PcTS) transforms iron‐induced oligomeric species of Aβ40 into amyloid fibrillar meshworks; this coincidentally eliminates redox‐active metal ions and oligomeric species, both of which are toxic candidates.