Click Chemistry as an Efficient Method for Preparing a Sensitive DNA Probe for Photochemical Ligation | Zendy

Ami Takehiro | Zendy; Fujimoto Kenzo | Zendy

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Click Chemistry as an Efficient Method for Preparing a Sensitive DNA Probe for Photochemical Ligation

Author(s) -

Ami Takehiro,

Fujimoto Kenzo

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800316

Subject(s) - chemistry , click chemistry , dna , ligation , combinatorial chemistry , photochemistry , biochemistry , microbiology and biotechnology , biology

Speed of light : We report a new photosensitive probe that takes advantage of the electronic structural changes associated with the formation of triazole rings in Cu I ‐catalyzed Huisgen 1,3‐dipolar cycloadditions between organic azides and terminal alkynes. We have succeeded in performing photoligation on a timescale of seconds. We also report an efficient procedure using photochemical ligation for the preparation of a DNA probe for quick SNP typing.

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