Ultrasensitive Detection of DNA by PNA and Nanoparticle‐Enhanced Surface Plasmon Resonance Imaging | Zendy

D'Agata Roberta | Zendy; Corradini Roberto | Zendy; Grasso Giuseppe | Zendy; Marchelli Rosangela | Zendy; Spoto  Giuseppe | Zendy

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Ultrasensitive Detection of DNA by PNA and Nanoparticle‐Enhanced Surface Plasmon Resonance Imaging

Author(s) -

D'Agata Roberta,

Corradini Roberto,

Grasso Giuseppe,

Marchelli Rosangela,

Spoto Giuseppe

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800310

Subject(s) - peptide nucleic acid , surface plasmon resonance , oligomer , nanoparticle , nucleic acid , dna , nanotechnology , chemistry , materials science , biochemistry , organic chemistry

Femtomolar single‐base mismatch discrimination : A nanoparticle‐enhanced surface plasmon resonance imaging method for ultrasensitive detection of the selective hybridization between a peptide nucleic acid (PNA) oligomer and its complementary single‐stranded DNA target is described. The method allows a 1 f M sensitivity in single‐base mismatch discrimination with only 150 zeptomoles of the target molecules.

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