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Investigation into the Mechanism of Phenolic Couplings during the Biosynthesis of Glycopeptide Antibiotics
Author(s) -
Holding Andrew N.,
Spencer Jonathan B.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800303
Subject(s) - glycopeptide , biosynthesis , enzyme , mechanism (biology) , glycopeptide antibiotic , chemistry , amino acid , biochemistry , peptide , vancomycin , antibiotics , stereochemistry , combinatorial chemistry , bacteria , biology , genetics , philosophy , epistemology , staphylococcus aureus
Three haem‐containing P450 enzymes catalyse the phenolic cross links that occur during the biosynthesis of vancomycin‐like glycopeptides. By isotopically labelling amino acids within the peptide backbone, the mechanism of all three of these enzymes can be probed.
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