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Photocontrol of Genomic DNA Conformation by Using a Photosensitive Gemini Surfactant: Binding Affinity versus Reversibility
Author(s) -
Geoffroy Marie,
Faure Delphine,
Oda Reiko,
Bassani Dario M.,
Baigl Damien
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800235
Subject(s) - pulmonary surfactant , dna , chemistry , genomic dna , molecule , biophysics , biochemistry , biology , organic chemistry
Precious GEM : In this communication, we demonstrate that a photosensitive gemini surfactant (AzoGEM) can be used to control the conformation of individual genomic DNA molecules at a surfactant‐to‐DNA charge ratio near to unity, which is 1000 times smaller than that for the systems reported to date (AzoTAB). We analyze the AzoGEM–DNA and AzoTAB–DNA interactions in terms of binding affinity and reversibility.