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Submicromolar, Selective G‐Quadruplex Ligands from One Pot: Thermodynamic and Structural Studies of Human Telomeric DNA Binding by Azacyanines
Author(s) -
Persil Çetinkol Özgül,
Engelhart Aaron E.,
Nanjunda Rupesh K.,
Wilson W. David,
Hud Nicholas V.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800234
Subject(s) - g quadruplex , duplex (building) , chemistry , dna , ligand (biochemistry) , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , binding affinities , base pair , computational biology , selectivity , small molecule , stereochemistry , combinatorial chemistry , biochemistry , biology , receptor , catalysis
Bound to work : A molecular architecture with a shape that is slightly larger than a Watson–Crick base pair was investigated as a potential G‐quadruplex ligand. Azacyanines, which possess this architecture, were found to bind on the end of the quadruplex stack (as shown in the figure) and to exhibit high selectivity over duplex binding. The chemical properties, ease of synthesis, and great potential for modification make the azacyanines and their analogues attractive for development as G‐quadruplex ligands in drug development.