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Split‐Ubiquitin and the Split‐Protein Sensors: Chessman for the Endgame
Author(s) -
Müller Judith,
Johnsson Nils
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800190
Subject(s) - ubiquitin , proteomics , computational biology , systems biology , biology , nanotechnology , proteome , chemical biology , chess endgame , chemistry , microbiology and biotechnology , computer science , bioinformatics , biochemistry , materials science , artificial intelligence , gene
Split‐protein sensors are increasingly used as analytical tools to identify, measure, and manipulate protein–protein interactions in living cells. By using split‐ubiquitin as a representative example, their general and their specific properties as well as their diverse applications in proteomics, cell biology, and synthetic biology are discussed.