Glycomimetic Inhibitors of Mycobacterial Glycosyltransferases: Targeting the TB Cell Wall | Zendy

Lucas Ricardo | Zendy; Balbuena Patricia | Zendy; Errey James C. | Zendy; Squire Marie A. | Zendy; Gurcha Sudagar S. | Zendy; McNeil Michael | Zendy; Besra Gurdyal S. | Zendy; Davis Benjamin G. | Zendy

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Glycomimetic Inhibitors of Mycobacterial Glycosyltransferases: Targeting the TB Cell Wall

Author(s) -

Lucas Ricardo,

Balbuena Patricia,

Errey James C.,

Squire Marie A.,

Gurcha Sudagar S.,

McNeil Michael,

Besra Gurdyal S.,

Davis Benjamin G.

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800189

Subject(s) - glycosyltransferase , mycobacterium tuberculosis , cell wall , computational biology , enzyme , mycobacterium , biochemistry , chemistry , biology , tuberculosis , microbiology and biotechnology , genetics , bacteria , medicine , pathology

Tear down the wall : Ready methods for the construction of libraries of both α‐ and β‐aza‐ C ‐rhamnomimetics with high levels of diastereoselectivity have allowed the identification of inhibitors of rhamnosyl‐processing enzymes. These include the first examples of analogues of the Mycobacterium tuberculosis sugar L ‐rhamnose that are inhibitors of mycobacterial biosynthetic pathways.

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