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Glycomimetic Inhibitors of Mycobacterial Glycosyltransferases: Targeting the TB Cell Wall
Author(s) -
Lucas Ricardo,
Balbuena Patricia,
Errey James C.,
Squire Marie A.,
Gurcha Sudagar S.,
McNeil Michael,
Besra Gurdyal S.,
Davis Benjamin G.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800189
Subject(s) - glycosyltransferase , mycobacterium tuberculosis , cell wall , computational biology , enzyme , mycobacterium , biochemistry , chemistry , biology , tuberculosis , microbiology and biotechnology , genetics , bacteria , medicine , pathology
Tear down the wall : Ready methods for the construction of libraries of both α‐ and β‐aza‐ C ‐rhamnomimetics with high levels of diastereoselectivity have allowed the identification of inhibitors of rhamnosyl‐processing enzymes. These include the first examples of analogues of the Mycobacterium tuberculosis sugar L ‐rhamnose that are inhibitors of mycobacterial biosynthetic pathways.