Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations | Zendy

Angelovski Goran | Zendy; Fouskova Petra | Zendy; Mamedov Ilgar | Zendy; Canals Santiago | Zendy; Toth Eva | Zendy; Logothetis Nikos K. | Zendy

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Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations

Author(s) -

Angelovski Goran,

Fouskova Petra,

Mamedov Ilgar,

Canals Santiago,

Toth Eva,

Logothetis Nikos K.

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800165

Subject(s) - extracellular , moiety , magnetic resonance imaging , egta , functional magnetic resonance imaging , function (biology) , calcium imaging , chemistry , calcium , order (exchange) , nuclear magnetic resonance , biophysics , biochemistry , computer science , neuroscience , physics , biology , microbiology and biotechnology , stereochemistry , medicine , organic chemistry , radiology , finance , economics

Image brain function : Gd 3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca 2+ fluctuations in the brain. Upon interaction with Ca 2+ , they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca 2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.

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