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Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations
Author(s) -
Angelovski Goran,
Fouskova Petra,
Mamedov Ilgar,
Canals Santiago,
Toth Eva,
Logothetis Nikos K.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800165
Subject(s) - extracellular , moiety , magnetic resonance imaging , egta , functional magnetic resonance imaging , function (biology) , calcium imaging , chemistry , calcium , order (exchange) , nuclear magnetic resonance , biophysics , biochemistry , computer science , neuroscience , physics , biology , microbiology and biotechnology , stereochemistry , medicine , organic chemistry , radiology , finance , economics
Image brain function : Gd 3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca 2+ fluctuations in the brain. Upon interaction with Ca 2+ , they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca 2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.