Glycosylation of Acyclic and Cyclic Aglycone Substrates by Macrolide Glycosyltransferase DesVII/DesVIII: Analysis and Implications | Zendy

Borisova Svetlana A. | Zendy; Kim Hak Joong | Zendy; Pu Xiaotao | Zendy; Liu Hungwen | Zendy

Premium

Glycosylation of Acyclic and Cyclic Aglycone Substrates by Macrolide Glycosyltransferase DesVII/DesVIII: Analysis and Implications

Author(s) -

Borisova Svetlana A.,

Kim Hak Joong,

Pu Xiaotao,

Liu Hungwen

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800155

Subject(s) - aglycone , glycosylation , glycosyltransferase , chemistry , enzyme , biochemistry , stereochemistry , glycoside

Studies of the macrolide glycosyltransferase , DesVII/DesVIII, showed that when multiple hydroxyl groups are present, no regiospecificity of glycosylation is observed for the linear substrates. In contrast, when cyclic substrates with multiple glycosylation sites were tested, it displayed excellent regiospecificity in most cases. These results clearly indicate that this enzyme pair is a valuable tool for glycodiversification.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research