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Glycosylation of Acyclic and Cyclic Aglycone Substrates by Macrolide Glycosyltransferase DesVII/DesVIII: Analysis and Implications
Author(s) -
Borisova Svetlana A.,
Kim Hak Joong,
Pu Xiaotao,
Liu Hungwen
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800155
Subject(s) - aglycone , glycosylation , glycosyltransferase , chemistry , enzyme , biochemistry , stereochemistry , glycoside
Studies of the macrolide glycosyltransferase , DesVII/DesVIII, showed that when multiple hydroxyl groups are present, no regiospecificity of glycosylation is observed for the linear substrates. In contrast, when cyclic substrates with multiple glycosylation sites were tested, it displayed excellent regiospecificity in most cases. These results clearly indicate that this enzyme pair is a valuable tool for glycodiversification.