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Dehydrophenylalanine (ΔPhe) as a β Breaker: Extended Structure Terminated by a ΔPhe‐Induced Turn in the Pentapeptide Boc‐Phe1‐Ala2‐Ile3‐ΔPhe4‐Ala5‐OMe
Author(s) -
Gupta Madhvi,
Acharya Rudresh,
Mishra Aseem,
Ramakumar Suryanarayanarao,
Ahmed Faizan,
Chauhan Virander Singh
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800053
Subject(s) - pentapeptide repeat , circuit breaker , stereochemistry , chemistry , sequence (biology) , peptide , residue (chemistry) , computer science , biochemistry , physics , quantum mechanics
Breaking the sheets : Crystallography studies illustrated the potential of α,β‐dehydrophenylalanine (ΔPhe) to interrupt the propagation of an extended structure in the de novo designed pentapeptide 1 . To further explore the role of ΔPhe as a β‐breaker residue, it was incorporated into the 16–20 segment of the Aβ 1–40 sequence. TEM studies suggest that ΔPhe might be useful as a β breaker in peptide‐based antifibrillizing drugs.