Dehydrophenylalanine (ΔPhe) as a β Breaker: Extended Structure Terminated by a ΔPhe‐Induced Turn in the Pentapeptide Boc‐Phe1‐Ala2‐Ile3‐ΔPhe4‐Ala5‐OMe | Zendy

Gupta Madhvi | Zendy; Acharya Rudresh | Zendy; Mishra Aseem | Zendy; Ramakumar Suryanarayanarao | Zendy; Ahmed Faizan | Zendy; Chauhan Virander Singh | Zendy

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Dehydrophenylalanine (ΔPhe) as a β Breaker: Extended Structure Terminated by a ΔPhe‐Induced Turn in the Pentapeptide Boc‐Phe1‐Ala2‐Ile3‐ΔPhe4‐Ala5‐OMe

Author(s) -

Gupta Madhvi,

Acharya Rudresh,

Mishra Aseem,

Ramakumar Suryanarayanarao,

Ahmed Faizan,

Chauhan Virander Singh

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800053

Subject(s) - pentapeptide repeat , circuit breaker , stereochemistry , chemistry , sequence (biology) , peptide , residue (chemistry) , computer science , biochemistry , physics , quantum mechanics

Breaking the sheets : Crystallography studies illustrated the potential of α,β‐dehydrophenylalanine (ΔPhe) to interrupt the propagation of an extended structure in the de novo designed pentapeptide 1 . To further explore the role of ΔPhe as a β‐breaker residue, it was incorporated into the 16–20 segment of the Aβ 1–40 sequence. TEM studies suggest that ΔPhe might be useful as a β breaker in peptide‐based antifibrillizing drugs.

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