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The Fluorescent Amino Acid p ‐Cyanophenylalanine Provides an Intrinsic Probe of Amyloid Formation
Author(s) -
Marek Peter,
Gupta Ruchi,
Raleigh Daniel P.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800052
Subject(s) - fluorescence , amyloid (mycology) , chemistry , biophysics , amyloid β , biochemistry , biology , medicine , physics , pathology , optics , inorganic chemistry , disease
Subtle ways : Analogues of amyloid‐forming polypeptides have been developed by using p ‐cyanophenylalanine as a sensitive, noninvasive, intrinsic probe of amyloid formation. p ‐Cyanophenylalanine (see figure) is a very conservative substitution for phenylalanine or tyrosine, and its fluorescence is incredibly sensitive to the environment; these facets make it a powerful probe of amyloid formation.