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Light‐Regulated RNA–Small Molecule Interactions
Author(s) -
Young Douglas D.,
Deiters Alexander
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800051
Subject(s) - aptamer , rna , spiropyran , small molecule , computational biology , chemistry , molecule , gene expression , gene , biophysics , microbiology and biotechnology , biology , biochemistry , organic chemistry
Regulating RNA with light . An RNA aptamer capable of specifically binding one isomer of a photoisomerizable spiropyran small molecule was engineered. The reversibility of the light‐switchable aptamer recognition was then characterized by SPR imaging. This RNA–small molecule pair has significant implications in the light‐regulation of biological functions and the reversible control of gene expression.