Peptide Tertiary Structure Nucleation by Side‐Chain Crosslinking with Metal Complexation and Double “Click” Cycloaddition | Zendy

Torres Oscar | Zendy; Yüksel Deniz | Zendy; Bernardina Matt | Zendy; Kumar Krishna | Zendy; Bong Dennis | Zendy

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Peptide Tertiary Structure Nucleation by Side‐Chain Crosslinking with Metal Complexation and Double “Click” Cycloaddition

Author(s) -

Torres Oscar,

Yüksel Deniz,

Bernardina Matt,

Kumar Krishna,

Bong Dennis

Publication year - 2008

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200800040

Subject(s) - cycloaddition , click chemistry , histidine , chemistry , side chain , peptide , combinatorial chemistry , nucleation , folding (dsp implementation) , chain (unit) , stereochemistry , organic chemistry , biochemistry , amino acid , catalysis , physics , astronomy , polymer , electrical engineering , engineering

Dimerization assist : Folding‐incompetent peptides are restored to dimerization capability by side‐chain crosslinking using both Ni 2+ –histidine complexation and a novel double “click” cycloaddition between the i and i +4 azidoalanine residues and synthetic bisalkyne linkers.

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