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Peptide Tertiary Structure Nucleation by Side‐Chain Crosslinking with Metal Complexation and Double “Click” Cycloaddition
Author(s) -
Torres Oscar,
Yüksel Deniz,
Bernardina Matt,
Kumar Krishna,
Bong Dennis
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800040
Subject(s) - cycloaddition , click chemistry , histidine , chemistry , side chain , peptide , combinatorial chemistry , nucleation , folding (dsp implementation) , chain (unit) , stereochemistry , organic chemistry , biochemistry , amino acid , catalysis , physics , astronomy , polymer , electrical engineering , engineering
Dimerization assist : Folding‐incompetent peptides are restored to dimerization capability by side‐chain crosslinking using both Ni 2+ –histidine complexation and a novel double “click” cycloaddition between the i and i +4 azidoalanine residues and synthetic bisalkyne linkers.