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Tetrameric β 3 ‐Peptide Bundles
Author(s) -
Goodman Jessica L.,
Molski Matthew A.,
Qiu Jade,
Schepartz Alanna
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800039
Subject(s) - bundle , identity (music) , peptide , valine , core (optical fiber) , series (stratigraphy) , stoichiometry , canonical bundle , set (abstract data type) , chemistry , stereochemistry , crystallography , computer science , mathematics , combinatorics , pure mathematics , biology , physics , amino acid , biochemistry , materials science , organic chemistry , programming language , telecommunications , paleontology , acoustics , composite material
A question of identity : There is significant interest in the design of discrete, nonproteinaceous quaternary structures. We recently described a series of β 3 ‐peptides that assemble into stable octameric bundles. Here we show that bundle stoichiometry is controlled by the bundle core side‐chain identity, whereby mutation of leucine to valine supports formation of discrete and stable tetrameric bundles.