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Novel DNA Catalysts Based on G‐Quadruplex Recognition
Author(s) -
Tang Zhuo,
Gonçalves Diana P. N.,
Wieland Markus,
Marx Andreas,
Hartig Jörg S.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200800024
Subject(s) - aldol reaction , dna , g quadruplex , aldehyde , catalysis , porphyrin , ketone , hero , chemistry , small molecule , dioxygenase , computational biology , combinatorial chemistry , stereochemistry , biology , computer science , biochemistry , organic chemistry , gene , artificial intelligence
An unlikely hero : Selective small‐molecule recognition of a specific DNA secondary structure, instead of hybridization, can be exploited to template catalysis between two reactants. Here, we show that a proline‐tethered quadruplex DNA, as shown in the figure, can serve as catalyst for the aldol reaction between a porphyrin‐bearing aldehyde and a ketone.
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