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Cover Picture: How Rapidly Do Epoxides Nonspecifically Form Covalent Bonds with Thiols in Water (ChemBioChem 16/2007)
Author(s) -
Albert Brian J.,
Koide Kazunori
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200790056
Subject(s) - epoxide , chemistry , nucleophile , bovine serum albumin , glutathione , covalent bond , reactivity (psychology) , cover (algebra) , affinities , intracellular , stereochemistry , combinatorial chemistry , organic chemistry , enzyme , biochemistry , catalysis , mechanical engineering , engineering , medicine , alternative medicine , pathology
The cover picture shows a cell treated with epoxide‐containing compounds. There is concern about the reactivity of epoxides towards the most abundant and powerful nucleophile, thiols, in a biological setting. However, the kinetic data presented in this article indicate that these epoxides are able to reach their biological targets without nonspecific reactions with endogenous extra‐ and intracellular thiols such as glutathione and albumin. Data were obtained for the consumption of five common epoxide motifs under biologically relevant conditions by using N ‐acetylcysteamine and bovine serum albumin as model thiols. Further details can be found in the article by B. J. Albert and K. Koide on p. 1912 ff.