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Cover Picture: A Structure–Activity Guided Strategy for Fluorescent Labeling of Annonaceous Acetogenin Mimetics and their Application in Cell Biology (ChemBioChem 2/2007)
Author(s) -
Liu HaiXia,
Huang GuoRui,
Zhang HuanMing,
Jiang Sheng,
Wu JiaRui,
Yao ZhuJun
Publication year - 2007
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200790000
Subject(s) - fluorescence , acetogenin , cancer cell , cover (algebra) , cell , biology , chemistry , biochemistry , combinatorial chemistry , computational biology , biophysics , stereochemistry , cancer , genetics , mechanical engineering , botany , physics , annonaceae , quantum mechanics , engineering
The cover picture shows an imaging study of a cytotoxic small molecule AA005, which is able to recognize and enter human cancer cells selectively. Fluorescent labeling of AA005 was successfully accomplished by a bioactivity assessment‐aided protocol after examining a number of potential derivative positions in parallel. AA005‐flu was found to exhibit similar cell selectivity to its parent molecule AA005. Fluorescent images of AA005‐flu show a significant difference in drug distribution between cancerous and normal cells, with accumulation of AA005‐flu occurring in the mitochondria of cancers cells. For more information, see the article by Z.‐J. Yao et al. on p. 172 ff.