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Protein Surface Recognition: Structural Characterisation of Cytochrome c–Porphyrin Complexes
Author(s) -
Crowley Peter B.,
Ganji Prasad,
Ibrahim Hasim
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700736
Subject(s) - porphyrin , surface protein , cytochrome c , chemistry , cytochrome , stereochemistry , crystallography , biophysics , biochemistry , biology , mitochondrion , enzyme , virology
Pattern recognition . Chemical‐shift‐perturbation mapping was used to identify the region of the cytochrome c surface that binds negatively charged porphyrin ligands. Protein–porphyrin binding appears to involve a dynamic ensemble of interactions in which the porphyrin is free to explore different surface patches on the protein.