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BODIPY‐Based Fluorescent Redox Potential Sensors that Utilize Reversible Redox Properties of Flavin
Author(s) -
Yamada Yasuyuki,
Tomiyama Yumiko,
Morita Akinori,
Ikekita Masahiko,
Aoki Shin
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700718
Subject(s) - redox , bodipy , flavin group , linker , moiety , chemistry , fluorescence , photochemistry , combinatorial chemistry , aqueous solution , flavin adenine dinucleotide , computer science , stereochemistry , biochemistry , organic chemistry , physics , quantum mechanics , enzyme , operating system , cofactor
Back and forth . Redox potential sensors that consist of a flavin unit, a bora‐3a,4a‐diaza‐ s ‐indacene (BODIPY) moiety, and a L ‐proline linker are presented. While reduced forms of these fluorescent sensors are almost nonfluorescent, their oxidized forms exhibit bright emissions under control of the redox status of the flavin unit. It is also shown that these changes are reversible in aqueous solutions and living cells, as illustrated in the figure.