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Polarity of Major Grooves Explored by Using an Isosteric Emissive Nucleoside
Author(s) -
Sinkeldam Renatus W.,
Greco Nicholas J.,
Tor Yitzhak
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700714
Subject(s) - polarity (international relations) , nucleoside , thymine , nucleobase , dna , solvent polarity , furan , groove (engineering) , chemistry , stereochemistry , solvent , biophysics , nanotechnology , biology , materials science , biochemistry , organic chemistry , cell , metallurgy
Feelin' groovy : An emissive furan‐containing nucleoside, which serves as a minimally invasive isomorphic thymine analogue, was used to estimate groove polarity in DNA. By determining the associated microscopic solvent‐polarity value E T (30) as shown in the figure, a rather apolar environment was detected. Such studies are likely to shed new light on fundamentally important questions regarding biopolymeric microenvironments.