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Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical “Starter‐Unit Effect”
Author(s) -
Crawford Jason M.,
Vagstad Anna L.,
Whitworth Karen P.,
Ehrlich Kenneth C.,
Townsend Craig A.
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700702
Subject(s) - polyketide , starter , stereochemistry , chemistry , unit (ring theory) , biochemistry , enzyme , biosynthesis , food science , mathematics , mathematics education
Getting started : The starter‐unit effect in fungal polyketides stems from s tarter unit: a cyl‐carrier protein t ransacylase (SAT) domains found in nonreducing polyketide synthases (PKSs). Dissection of the PKSs involved in the production of naphthopyrone YWA1, tetrahydroxynaphthalene, cercosporin, and bikaverin revealed that their SAT domains had high selectivity for acetyl‐CoA (see figure); this provides a biochemical rationale for this classically observed effect.