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Discovery of Chromone‐Based Inhibitors of the Transcription Factor STAT5
Author(s) -
Müller Judith,
Sperl Bianca,
Reindl Wolfgang,
Kiessling Anke,
Berg Thorsten
Publication year - 2008
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200700701
Subject(s) - chromone , transcription factor , transcription (linguistics) , stat5 , computational biology , gene , biology , chemistry , genetics , philosophy , linguistics
Obstacles overcome : Gene‐specific transcription factors are emerging therapeutic targets, but their direct inhibition is considered to be difficult because of the absence of enzymatic activities. This manuscript describes the discovery of chromone‐based inhibitors of the protein–protein interactions required for activity of the transcription factor STAT5, a therapeutic target for the treatment of human cancers.